OBJECTIVES: This study aimed to determine the prevalence of and risk factors for colonization with extended-spectrum β-lactamase-producingEnterobacteriaceae (ESBL-E) and methicillin-resistant Staphylococcus aureus (MRSA) in very low birth weight (VLBW; <1500 g) infants and their mothers.

METHODS: This investigation was conducted in the perinatal centre at the Charité Berlin between May 2012 and June 2013. VLBW infants and their mothers were screened for colonization with ESBL-E and MRSA. Demographic and clinical data were obtained from the German nationwide surveillance system for nosocomial infections in VLBW infants (NEO-KISS) and used to perform univariate and multivariate analyses.

RESULTS: Of 209 VLBW infants, 12 (5.7%) were colonized with ESBL-E. Eighteen of 209 (8.6%) ESBL-E-tested neonates were related to anESBL-E-positive mother. Univariate analysis, strain typing and multivariate analysis (OR 7.4, 95% CI 2.1-26.7, P = 0.002) identified an ESBL-E-positive mother and maternal-neonatal transmission as a main source of colonization. The prevalence of MRSA was 2.3% (5 of 221) amongVLBW infants. One of the 221 (0.5%) MRSA-tested neonates was related to an MRSA-positive mother. No risk factors for transmission of MRSA could be detected in this study.

CONCLUSIONS: Our study demonstrated that maternal-neonatal transmission of ESBL-E from mother to child is an important risk factor forcolonization of VLBW infants. As a consequence, routine ESBL-E screening of neonates and mothers should be considered as a means of reducing neonatal morbidity and mortality.

Authors: Denkel LA, Schwab F, Kola A, Leistner R, Garten L, von Weizsacker K, Geffers C, Gastmeier P, Piening B

Voor het volledige artikel klik hier (J Antimirob Chemother. 2014 Apr 11)

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