Recently, plasmid-mediated colistin resistance was reported in humans, animals and food. We studied the presence of mcr-1 and mcr-2 in Dutch retail chicken meat. The prevalence of mcr-1 was 24,8% (53/214), whereas mcr-2 was not found. The presence of mcr-1-positive Enterobacteriaceae was confirmed by culture in 34/53 samples (64,2%). The prevalence depended on the supermarket chain and was lower in free-range chicken samples. The unexpected high prevalence of mcr-1 in food is cause for concern.

Recently, a plasmid-mediated colistin resistance gene, called mcr-1, was reported from China [1], which was soon followed by several reports on mcr-1 positive Enterobacteriaceae from food, animals and the environment across the world [23]. This is of particular concern as colistin is currently considered as a last resort agent for treatment of infections with isolates that contain other resistance traits, like extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae or carbapenem-resistant bacteria [456].

Recent investigations using metagenomics, indicated a substantial larger environmental reservoir regarding the mcr-1 gene in the Chinese population [7]. This indicates that other approaches are needed to reveal the true reservoir of mcr-1.

In the Netherlands, mcr-1 was detected at low prevalence in E. coli isolates from livestock and meat (< 2%) and at very low frequencies in the human population [689]. The aim of this study was to determine the prevalence of mcr-1 and mcr-2 in a collection of poultry samples from Dutch supermarkets using a PCR-based method…….

published in ARIC Journal, klik hier voor volledig artikel 

Authors: Eefje J. A. Schrauwen (1,2), Pepijn Huizinga (1,3), Nick van Spreuwel (1,2), Carlo Verhulst (1), Marjolein F. Q. Kluytmans-van den Bergh (1,4,5) and Jan A. J. W. Kluytmans (1,5,6)

1 Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands
2 Academy for Technology and Environmental Health, Avans University of Applied Sciences, Breda, the Netherlands
3 Laboratory for Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.
4 Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
5nAmphia Academy Infectious Disease Foundation, Amphia Hospital, Breda, The Netherlands.
6 Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands. 

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