Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)- producing Escherichia coli in veterinary hospital staff and students

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Extended-spectrum β-lactamase (ESBL)-producing bacteria causing clinical infections are often also multidrug-resistant (MDR; resistance to ≥3 antimicrobial drug classes), therefore treatment options may be limited. High carriage rates of these potentially zoonotic bacteria have been found in livestock and companion animals. Therefore, people working in veterinary hospitals may be a high-risk population for carriage. This is the […]

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  • op 17 februari 2019
  • door dTHIP redactie

Katheter en infuus vaak onnodig én pijnlijk

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Veel patiënten met een urinekatheter of een perifeer infuus ervaren daar ongemak of klachten van, zonder dat verpleegkundigen of artsen hiervan weten. Ook weten veel patiënten niet waarom ze überhaupt een katheter of infuus hebben. Lees gehele artikel in nursing 4 februari 2019, klik hier

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  • door dTHIP redactie

The socio-economic impact of multidrug-resistant nosocomial infections: a qualitative study

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The burden of healthcare-associated infections (HCAIs) has traditionally been measured using clinical and economic outcomes. We conducted semi-structured interviews with 18 patients or their caregivers affected by HCAI caused by multidrug-resistant organisms to better understand the human impact of HCAI. Most patients had misconceptions about HCAI and antimicrobial resistance, leading to strong negative feelings towards […]

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  • op 24 januari 2019
  • door dTHIP redactie

Bronchoscope-associated clusters of multidrug-resistant Pseudomonas aeruginosa and carbapenem-resistant Klebsiella pneumoniae

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OBJECTIVE: Recovery of multidrug-resistant (MDR) Pseudomonas aeruginosa and Klebsiella pneumoniae from a cluster of patients in the medical intensive care unit (MICU) prompted an epidemiologic investigation for a common exposure. METHODS: Clinical and microbiologic data from MICU patients were retrospectively reviewed, MICU bronchoscopes underwent culturing and borescopy, and bronchoscope reprocessing procedures were reviewed. Bronchoscope and clinical MDR […]

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Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach

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Objectives: With increasing global interest in hospital antimicrobial stewardship (AMS) programmes, there is a strong demand for core elements of AMS to be clearly defined on the basis of principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was […]

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  • door dTHIP redactie

A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: A Randomized Clinical Trial

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Objectives: Intestinal carriage with extended spectrum beta-lactamase (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) can persist for months. We aimed to evaluate whether oral antibiotics followed by faecal microbiota transplantation (FMT) can eradicate intestinal carriage with ESBL-E/CPE. Methods: Randomized, open-label, superiority trial in four tertiary care centres (Geneva [G], Paris [P], Utrecht [U], Tel Aviv [T]). Non-immunocompromised adult patients […]

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  • door dTHIP redactie

Proportion of asylum seekers carrying multi-drug resistant microorganisms is persistently increased after arrival in the Netherlands

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Background: Several studies have shown a high prevalence of multi-drug resistant organisms (MDRO) amongst asylum seekers when compared to the general population. The aim of this study is to assess the duration of MDRO carriage in this population. Methods: Data were retrospectively collected between January 1st 2014 through December 31st 2016. Study material included screening samples for […]

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  • door dTHIP redactie

Worldwide practices on flexible endoscope reprocessing

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Background Endoscopy related infections represent an important threat for healthcare systems worldwide. Recent outbreaks of infections with multidrug resistant micro-organisms have highlighted the problems of contaminated endoscopes. Endoscopes at highest risk for contamination have intricate mechanisms, multiple internal channels and narrow lumens that are especially problematic to clean. In light of raised awareness about the […]

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  • op 4 januari 2019
  • door Corianne Meijer

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza

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Abstract These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza pandemic. This document addresses new information regarding diagnostic testing, treatment and chemoprophylaxis with antiviral medications, and issues related to institutional outbreak management for seasonal influenza. It is […]

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  • door Corianne Meijer

Simplifying the WHO protocol: Three steps versus six steps for performance of hand hygiene – a cluster-randomized trial.

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BACKGROUND: In an experimental setting, a simplified 3-step hand hygiene technique for applying alcohol-based hand rub was non-inferior in terms of reduction of bacterial counts as compared to the conventional WHO-6-step technique. We therefore compared compliance and microbiological efficacy between both hand hygiene techniques in routine clinical practice. METHODS: We performed a cluster-randomized trial from […]

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  • op 17 december 2018
  • door dTHIP redactie