Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

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Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted […]

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  • op 17 december 2018
  • door dTHIP redactie

Hier dragen we goede hygiëne op handen

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Werk je in de zorgsector? Dan is goede handhygiëne van essentieel belang. Handen vormen namelijk de belangrijkste overdrachtsweg van micro-organismen. Handhygiëne is de meest doeltreffende maatregel ter preventie van zorginfecties en de verspreiding van (multiresistente) micro-organismen (onder andere bacteriën, virussen en schimmels). Met goede handhygiëne voorkom je enerzijds besmetting van de bewoner en van jezelf, […]

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  • door dTHIP redactie

The quality of studies evaluating antimicrobial stewardship interventions: a systematic review

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Antimicrobial stewardship aims to optimise antibiotic use and minimise selection of antimicrobial resistance. The methodological quality of published studies in this field is unknown. Our objective was to perform a comprehensive systematic review of antimicrobial stewardship research design and identify features which limit validity and translation of research findings into clinical practice. We extracted data on […]

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  • op 26 november 2018
  • door dTHIP redactie

Hand Hygiene in hospitals: Anatomy of a revolution.

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Healthcare-associated infections (HAI) affect hundreds of millions of individuals worldwide. Performing hand hygiene is widely accepted as a key strategy of infection prevention and control (IPC) to prevent HAI, as healthcare workers' contaminated hands are the vehicle most often implicated in the cross-transmission of pathogens in healthcare. In the last 20 years, a paradigm shift has occurred in handhygiene: […]

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Hand hygiene in intensive care units: a matter of time?

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Healthcare-associated infections are a frequent threat to patient safety and cause significant disease burden. The most important single preventive measure is hand hygiene (HH). Barriers to adherence with HH recommendations include structural aspects, knowledge gaps, and organizational issues, especially a lack of time in daily routine.

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  • op 25 november 2018
  • door dTHIP redactie

Behandeling van infecties met zeer resistente bacteriën

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Wereldwijd stijgt de prevalentie van carbapenemase-producerende Enterobacteriaceae en multiresistente Pseudomonas aeruginosa .Ook in Nederland worden we geconfronteerd met infecties met deze zeer resistente bacteriën. Voor de behandeling van dergelijke infecties baseert men zich op ervaringen uit casusbeschrijvingen en resultaten van retrospectieve studies.Trials naar mogelijke combinatietherapieën worden op dit moment opgezet of zijn net gestart. Er zijn op korte termijn geen nieuwe […]

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  • door dTHIP redactie

Beyond the hospital infection control guidelines: a qualitative study using positive deviance to characterize gray areas and to achieve efficacy and clarity in the prevention of healthcare-associated infections

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Background: The literature is replete with attempts to design and promote customized guidelines to reduce infections during the care continuum. Paradoxically, these efforts sometimes result in gray areas where many staff members are unaware of what is required of them, which then leads to confusion, frustration, and uncertainty. We coined the phrase “gray areas” in this context to […]

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  • op 29 oktober 2018
  • door dTHIP redactie

A large, refractory nosocomial outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli demonstrates carbapenemase gene outbreaks involving sink sites require novel approaches to infection control

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Carbapenem-resistant Enterobacteriaceae (CRE) are a health threat, but effective control interventions remain unclear. Hospital wastewater sites are increasingly highlighted as important potential reservoirs. We investigated a large Klebsiella pneumoniae carbapenemase (KPC)-producing E. coli (KPC-EC) outbreak and wider CRE incidence trends over eight years in the Central Manchester Foundation NHS Trust (CMFT), UK, to determine the impact of Infection Prevention and Control […]

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Increased Detection Of Carbapenemase-Producing Enterobacteriaceae On Post-Clean Sampling Of Burns Units Wet Surfaces

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Wet surface biofilms are a potential reservoir for multidrug-resistant Gram-negative organisms, including carbapenamase-producing Enterobacteriaceae (CPE). Recognition of environmental sources is important in reducing secondary patient transmission. We report the increased detection of bla-IMP-4+ CPE in environmental samples from floor drains in Burns Unit shower rooms, when collected following cleaning as compared to pre-cleaning. We propose that disruption of […]

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  • op 28 oktober 2018
  • door dTHIP redactie

Preoperative oral antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery: results from a before-after study

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Background: Surgical site infections (SSI) are common complications after colorectal procedures and remain an important source of morbidity and costs. Preoperative oral antibiotic prophylaxis is a potential infection control strategy, but its effectiveness without simultaneous use of mechanical bowel preparation (MBP) is unclear. In this study, we aimed to determine whether preoperative oral antibiotics reduce the […]

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  • door dTHIP redactie